<form id="xxxjb"><sub id="xxxjb"></sub></form>

    <dfn id="xxxjb"></dfn><em id="xxxjb"><span id="xxxjb"><pre id="xxxjb"></pre></span></em><strike id="xxxjb"></strike>
      <big id="xxxjb"></big>

      <menuitem id="xxxjb"></menuitem>
      <b id="xxxjb"><video id="xxxjb"></video></b>
      <strike id="xxxjb"></strike>

      <address id="xxxjb"></address>

        <span id="xxxjb"><nobr id="xxxjb"><pre id="xxxjb"></pre></nobr></span>

        <span id="xxxjb"><progress id="xxxjb"></progress></span>

        食品中砷及砷化合物的食用安全性評價
        DOI:
        作者:
        作者單位:

        作者簡介:

        作者簡介:尚德榮(1960-),女,高級工程師,主要從事營養與持久性污染物研究。E-mail:shangdr@ysfri.ac.cn 通信作者:趙艷芳,副研究員,主要從事元素形態分析及安全性評價研究。E-mail:zhaoyf@ysfri.ac.cn

        通訊作者:

        基金項目:

        農產品質量安全監管專項經費(2011);中華人民共和國農業行業標準(2008-10167)


        Safety evaluation of arsenic and arsenic coumpounds in food
        Author:
        Affiliation:

        Fund Project:

        • 摘要
        • |
        • 圖/表
        • |
        • 訪問統計
        • |
        • 參考文獻
        • |
        • 相似文獻
        • |
        • 引證文獻
        • |
        • 資源附件
          摘要:

          摘要:以聯合國糧農組織和世界衛生組織食品添加劑聯席專家委員會(JECFA)第72次會議對食品中砷暴露的風險評估報告為主要依據,結合無機砷的毒性、流行病學以及暴露評估研究(包括生物標志物研究、分析方法、形態學以及在食品及飲用水中的含量等),對砷及砷化合物毒性進行綜合評價,并重新評估和提出了每周容許攝入量值(PTWI)。基于暴露平均量, 經過平均11年半的跟蹤隨訪,委員會提出,癌癥發病率比背景值增長0.5%的最低每日基準劑量(BMD0.5)為3.0 μg/kg b.w.,通過對影響暴露評估的不確定性進行靈敏度調查分析,表明BMD0.5下限值(BMDL0.5)可能為每日2.0~7.0 μg/kg b.w.。委員會同時提出1988年第33次會議提出的暫定每周耐受攝入量(PTWI)(15 μg/kg b.w.,即每日2.1μg/kg b.w.)由于在BMDL0.5范圍內,因此不再適用并予以取消。[中國漁業質量與標準,2012,24):00-00]

          Abstract:

          Abstract: This paper was to evaluate health risk of arsenic from dietary exposure based on the newest JECFA report72rd. Considering all informations related to the toxicology and epidemiology, exposure assessment, including biomarker studies, analytical methodology, speciation and occurrence in food and drinking-water, a comprehensive evaluation on the toxicity of inorganic As and other arsenic compounds was proposed and the PTWI for inorganic  arsenic.was re-evaluated and reviewed. The lowest calculated BMDL was 3.0 μg/kg b.w. per day for a 0.5% increased incidence of lung cancer above background over the average 11.5 years of follow-up, based on average estimates of the exposure. A sensitivity analysis to investigate the impact of uncertainty in the exposure estimate in this study indicated that this BMDL0.5 could be in the range of 2.07.0 μg/kg b.w. per day. The Committee noted that the PTWI of 15 μg/kg b.w. 2.1 μg/kg b.w. per dayadvanced at the thirty-third meeting 1988is in the region of the BMDL0.5 and therefore was no longer appropriate and the Committee withdrew the previous PTWI. [Chinese Fishery Quality and Standards, 2012, 2(4):000-000]

          參考文獻
          相似文獻
          引證文獻
        引用本文

        尚德榮,趙艷芳*,郭瑩瑩,等.食品中砷及砷化合物的食用安全性評價[J].中國漁業質量與標準,2012,2(4):21-32. SHANG Derong, ZHAO Yanfang*,GUO Yingying, et al. Safety evaluation of arsenic and arsenic coumpounds in food[J]. Chinese Fishery Quality and Standards,2012,2(4):21-32.

        復制
        分享
        文章指標
        • 點擊次數:
        • 下載次數:
        歷史
        • 收稿日期:
        • 最后修改日期:2013-01-24
        • 錄用日期:
        • 在線發布日期:

          <form id="xxxjb"><sub id="xxxjb"></sub></form>

          <dfn id="xxxjb"></dfn><em id="xxxjb"><span id="xxxjb"><pre id="xxxjb"></pre></span></em><strike id="xxxjb"></strike>
            <big id="xxxjb"></big>

            <menuitem id="xxxjb"></menuitem>
            <b id="xxxjb"><video id="xxxjb"></video></b>
            <strike id="xxxjb"></strike>

            <address id="xxxjb"></address>

              <span id="xxxjb"><nobr id="xxxjb"><pre id="xxxjb"></pre></nobr></span>

              <span id="xxxjb"><progress id="xxxjb"></progress></span>

              骚屄视频