<form id="xxxjb"><sub id="xxxjb"></sub></form>

    <dfn id="xxxjb"></dfn><em id="xxxjb"><span id="xxxjb"><pre id="xxxjb"></pre></span></em><strike id="xxxjb"></strike>
      <big id="xxxjb"></big>

      <menuitem id="xxxjb"></menuitem>
      <b id="xxxjb"><video id="xxxjb"></video></b>
      <strike id="xxxjb"></strike>

      <address id="xxxjb"></address>

        <span id="xxxjb"><nobr id="xxxjb"><pre id="xxxjb"></pre></nobr></span>

        <span id="xxxjb"><progress id="xxxjb"></progress></span>

        阿維菌素在鱸組織中的富集及消除規律研究
        DOI:
        作者:
        作者單位:

        作者簡介:

        邢麗紅(1981-),女,助理研究員,主要從事水產品質量安全檢測及研究,xinglh@ysfri.ac.cn 通信作者:冷凱良,研究員,主要從事水產品加工及質量安全檢測研究,lengkl@ysfri.ac.cn;李兆新,副研究員,主要從事水產品質量安全檢測及研究,lizx@ysfri.ac.cn

        通訊作者:

        基金項目:

        國家科技支撐計劃(2012BAD29B00)


        Accumulation and elimination rules of avermectin in perch (Lateolabraxjaponicus)
        Author:
        Affiliation:

        Fund Project:

        • 摘要
        • |
        • 圖/表
        • |
        • 訪問統計
        • |
        • 參考文獻
        • |
        • 相似文獻
        • |
        • 引證文獻
        • |
        • 資源附件
          摘要:

          采用高效液相色譜熒光檢測器(HPLC-FLD)法測定鱸組織中殘留的阿維菌素,研究其在鱸體內的富集和消除規律。使用0.5 μg/L阿維菌素對初始體重為(120±15)g的鱸連續藥浴20 d,停藥后,采用高效液相色譜法測定肌肉、肝臟、鰓和血液組織中阿維菌素的殘留量。結果表明,阿維菌素能夠在鱸肌肉、肝臟、血液和鰓各組織中富集,但不同組織對阿維菌素的富集能力不同,肝臟的蓄積能力最強,而肌肉的蓄積能力最弱。肝臟中阿維菌素最高質量濃度(Cmax)可達87.36 μg/kg,藥時曲線下面積(AUC肝臟)為12 977.73 (μg/L)·h,而肌肉Cmax僅為7.74 μg/kg,AUC肌肉僅為2 105.75 (μg/L)·h,肌肉、鰓、肝臟和血液對阿維菌素的消除半衰期分別為6.9、9.5、8.2和10.7 d。由于影響水生生物藥代動力學的因素較多,同種藥物在不同水生生物體內的藥代動力學參數有很大差異。鱸在15~18 ℃條件下連續藥浴阿維菌素20 d,可食組織肌肉中阿維菌素的殘留量40 d后降至檢測限以下。本研究為今后在水產養殖中合理使用阿維菌素藥物提供了理論依據

          Abstract:

          The accumulation and elimination rules of avermectin in perch (Lateolabraxjaponicus) were studied and the avermectin residues in perch were determined with HPLC-fluorescence method. The perch with initial body weight of (120±15) g were dealt with 0.5 μg/L medicated bath for 20 d. After medicated bath was terminated, the avermectin retained in muscle, liver, gill and blood was determined. The results showed that avermectin could accumulate in muscle, liver, gill and blood of perch, but the enrichment capacity of each tissue was different. The enrichment capacity of avermectin was comparatively strong in the liver, but relatively weak in muscle. The Cmax of liver could reach 87.36 μg/kg,and AUCliver was 12 977.73 (μg/L)·h, whereas the Cmax of muscle was 7.74 μg/kg and AUCmuscle was only 2 105.75 (μg/L)·h. Elimination half-time of avermectin in the muscle, gill, liver and blood of perch were 6.9, 9.5, 8.2 and 10.7 d, respectively. Since many factors affected residues of aquatic animals, pharmacokinetic parameters of the same drug in different aquatic animals were very different. In this condition, when the temperature were 15-18℃, the residues of avermectin in muscle dropped to detection limit after 40 d. This study discussed the pharmacokinetics of avermectin in perch, and analyzed the content variations of the muscle, liver, gill and blood in perch with different time. The dynamic change rules of avermectin were clarified, which would provide theoretical basis for clinical medication in future.

          參考文獻
          相似文獻
          引證文獻
        引用本文

        邢麗紅,孫偉紅,冷凱良*,等.阿維菌素在鱸組織中的富集及消除規律研究[J].中國漁業質量與標準,2013,3(4):63-69. XING Lihong, SUN Weihong, LENG Kailiang*,et al. Accumulation and elimination rules of avermectin in perch (Lateolabraxjaponicus)[J]. Chinese Fishery Quality and Standards,2013,3(4):63-69.

        復制
        分享
        文章指標
        • 點擊次數:
        • 下載次數:
        歷史
        • 收稿日期:
        • 最后修改日期:2014-01-20
        • 錄用日期:
        • 在線發布日期:

          <form id="xxxjb"><sub id="xxxjb"></sub></form>

          <dfn id="xxxjb"></dfn><em id="xxxjb"><span id="xxxjb"><pre id="xxxjb"></pre></span></em><strike id="xxxjb"></strike>
            <big id="xxxjb"></big>

            <menuitem id="xxxjb"></menuitem>
            <b id="xxxjb"><video id="xxxjb"></video></b>
            <strike id="xxxjb"></strike>

            <address id="xxxjb"></address>

              <span id="xxxjb"><nobr id="xxxjb"><pre id="xxxjb"></pre></nobr></span>

              <span id="xxxjb"><progress id="xxxjb"></progress></span>

              骚屄视频